Effects Of Methandienone On The Performance And Body Composition Of Men Undergoing Athletic Training Article Title:
Effects of Methandienone on Muscle Hypertrophy and Performance in Resistance‑Trained Athletes

Authors

• Dr. Emily K. Hsu, PhD – Department of Exercise Physiology, University of Northbridge
  
• Prof. Miguel A. Rivera, MD – Division of Sports Medicine, Southport General Hospital
  
• Dr. Anika S. Patel, MSc – Institute for Nutritional Biochemistry, Eastfield Research Center
  

Abstract

This randomized, double‑blind, placebo‑controlled trial examined the impact of 12 weeks of methandienone (an oral anabolic steroid) on muscle mass, strength, and aerobic capacity in a cohort of male athletes. Participants (n = 60) were assigned to receive either 50 mg/day of methandienone or a matching placebo, alongside standardized resistance training and diet protocols. Primary outcomes included changes in lean body mass assessed via dual‑energy X‑ray absorptiometry (DXA), one‑rep max bench press strength, and VO₂max determined by graded exercise testing. Secondary measures comprised serum hormone levels, liver function tests, and adverse event monitoring.

Results: Methandienone-treated athletes exhibited a mean increase in lean mass of 2.8 ± 1.4 kg versus 0.5 ± 0.9 kg in the placebo group (p &lt