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These tails are topic to a number of submit-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 household, members of which methylate K79 in the globular region of histone H3 and legal professional that are structurally not associated to SET-domain proteins four - 6 Recent work suggests that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)
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